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. 2020 Oct 28;6(44):eabb0025. doi: 10.1126/sciadv.abb0025

Fig. 5. Histological analysis of tissues surrounding implants incubated in bacterial suspension for 12 hours.

Fig. 5

(A) Schematics of the biofilm formation and spreading mechanism on the infected orthopedic implant’s surface. eDNA, extracellular DNAs. (B) Schematics of immune response upon the orthopedic implants’ insertion. (C) H&E staining and (D) MT staining of the tissues around the orthopedic implants of bare positive and LOIS. IHC of immune-related cytokines, (E) TNF-α and (F) IL-6, staining images of the rabbit implanted with bare negative and LOIS. (G) Quantification of the cytokine expression via area coverage measurements (**P < 0.01).