Fig. 1. The molecular architecture of SugABC.

(A) Cartoon representation of SugABC viewed from with the membrane represented by the gray box. SugA and SugB are colored violet and peach, respectively. SugC is colored green or gray. The coupling helices in SugA and SugB are also marked by dashed boxes. (B) Clipped view of the transmembrane region of SugABC viewed from the periplasm. The star indicates the pseudo-twofold axis. (C) Superposition of SugA and SugB structures. (D) Topological diagram of SugA or SugB.