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. 2020 Oct 30;6(44):eabc9174. doi: 10.1126/sciadv.abc9174

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 4 — (A) Exemplar K_2P2.1 (TREK-1) single-channel recordings at −100 mV before (left) and after (right) application of 30 μM ML335 to the same cell-attached patch. (B) Exemplar K_2P2.1 (TREK-1) single-channel recordings at −100 mV in the presence of 5 μM ML335 applied in the pipette solution of a cell-attached patch. (C) Open channel probability at −100 mV from single-channel analysis calculated on recordings of ≥30-s duration. (D and E) Single-channel amplitude at (D) −100 mV and (E) +50 mV. Error bars indicate SEM (n = 5 to 7). “**” indicates P < 0.01 and “N.S.” indicates not statistically different relative to K_2P2.1 (TREK-1).