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. 2020 Oct 23;6(43):eaba0942. doi: 10.1126/sciadv.aba0942

Fig. 4. L-AgÅPs-gel accelerates the healing of skin diabetic wounds.

Fig. 4

(A) Release curve of silver from L-AgÅPs-gel packaged in a biomimetic membrane. (B) Gross view of diabetic wounds from female mice treated with blank-gel, L-AgÅPs-gel, or AgNPs-gel at the indicated time points. Scale bar, 2 mm. (C) The rate of wound closure. n = 10 per group. 1 − β = 1. D1, day 1. (D) The time for complete closure of diabetic wounds. n = 10 per group. (E) H&E staining of diabetic wounds. Double-headed arrows indicate the scars. Scale bar, 500 μm. (F and G) Quantification of the re-epithelialization rates (F) and scar widths (G). n = 5 per group. 1 − β = 0.99. (H and I) Masson’s trichrome staining images of diabetic wounds (H) and quantification of the average intensity for Masson-stained areas (I). Scale bar, 100 μm (top) and 50 μm (bottom). n = 5 per group. 1 − β = 0.99. (J and K) Immunohistochemical staining for ki67 in diabetic wounds (J) and quantification of the numbers of ki67-positive cells (K). Scale bar, 50 μm. n = 5 per group. 1 − β = 1. For (C), *P < 0.05 versus blank-gel group, #P < 0.05 versus AgNPs-gel group. *P < 0.05, **P < 0.01, and ***/###P < 0.001. Photo credit: Chun-Yuan Chen and Hao Yin, Central South University.