Table 1.

Optimization of Palladium-Catalyzed Allylic Alkylation^a,b

entry	ligand	solvent	%eec (yield)
1	L1	2:1 hexane/PhMe	−51
2	L2	2:1 hexane/PhMe	34
3	L1	2:1 hexane/PhMe	85
4	L4	2:1 hexane/PhMe	84
5	L3	benzene	80
6	L3	methylcyclohexane	81
7d	L3	2:1 hexane/PhMe	86 (96)

^aConditions: 0.1 mmol 1a, 2.5 mol % Pd₂(dba)₃, 6 mol % ligand, 2.0 mL solvent.

^bConversion over 95% if no yield from isolated product stated.

^cDetermined by chiral SFC analysis.

^dReaction performed with 0.2 mmol 1a, 0.25 mol % Pd₂(dba)₃, 0.6 mol % ligand, and 2.0 mL solvent.