Table 2.

Substrate Scope of the Enantioselective Decarboxylative Allylic Alkylation of Enaminones^a

entry	product	R1	R2	yield (%)b	ee (%)c
1	2a	Me	H	95 (93)d	99 (98)d
2	2b	Et	H	99	98
3	2c	CH2OTBS	H	96	99
4	2d	CH2CH2OTBS	H	93	99
5	2e	CH2CH2CO2Me	H	98	97
6	2f	CH2CH2C(O)Me	H	90	94
7	2g	CH2CH2CN	H	99	94
8	2h	Bn	H	95	96
9	2i	p-(OMe)Bn	H	99	95
10	2j	p-(CF3)Bn	H	87	92
11	2k	Me	Me	92	99
12	2l	Me	Cl	58	99

^aConditions: β-ketoester (0.47 mmol), Pd₂(dmdba)₃ (5.0 mol %), (S)-t-BuPHOX (12.5 mol %), EtOAc (14 mL), 40 °C, 9 h.

^bIsolated yield.

^cDetermined by analytical chiral SFC. See Supporting Information for details.

^dConditions: β-ketoester (12.3 mmol), Pd₂(dmdba)₃ (0.5 mol %), (S)-t-BuPHOX (1.3 mol %), EtOAc (37 mL), 40 °C.