Table 3.

Further Structural Variation of Enaminone^a

substrate	product	yield (%)b	ee (%)c
		95	99
		99	99
		52	90
		93	72
		94	83

^aConditions: β-ketoester (0.47 mmol), Pd₂(dmdba)₃ (5.0 mol %), (S)-t-BuPHOX (12.5 mol %), EtOAc (14 mL), 40 °C.

^bIsolated yield.

^cDetermined by analytical chiral SFC. See Supporting Information for details. Values in red highlight deviations from those of model substrate 2a.