. 2020 Nov 3;15(11):e0241742. doi: 10.1371/journal.pone.0241742

Table 3. Meta-analyses of body mass index and laboratorial potential predictors of in-hospital mortality.

Potential predictor	Reference range	Studies, n	Non-survivors		Survivors		Effect estimates
			Patients, n	Pooled Mean	Patients, n	Pooled Mean (95% CI)	Pooled Mean difference (95%CI)	Effect size (95% CI)	p-value	I²
			Patients, n	(95% C I)	Patients, n	Pooled Mean (95% CI)	Pooled Mean difference (95%CI)	Effect size (95% CI)	p-value	I²
BMI (kg/m²)	18.5–24.9	6	1237	27.54	2887	27.88	-0.13	-0.01	0.925	89.1
BMI (kg/m²)	18.5–24.9	6	1237	(26.91, 28.18)	2887	(26.73, 29.03)	(-0.70, 0.44)	(-0.29, 0.27)	0.925	89.1
Routine blood tests
Lymphocyte count(x10⁹/L)	1.0–4.0	26	3121	0.69	12876	1.06	-0.36	-1.97	<0.001	99.3
Lymphocyte count(x10⁹/L)	1.0–4.0	26	3121	(0.57, 0.82)	12876	(0.91, 1.21)	(-0.52, -0.20)	(-2.55, -1.38)^*	<0.001	99.3
Leucocyte count (x10⁹/L)	3.6–11.0	26	2515	8.56	10959	5.92	2.75	1.79	<0.001	98.6
Leucocyte count (x10⁹/L)	3.6–11.0	26	2515	(8.09, 9.03)	10959	(5.06, 6.23)	(2.02, 3.49)	(1.32, 2.25)^*	<0.001	98.6
Neutrophil count (x10⁹/L)	1.8–6.3	19	2195	7.18	9313	4.53	2.69	2.20	<0.001	99.0
Neutrophil count (x10⁹/L)	1.8–6.3	19	2195	(6.77, 7.59)	9313	(3.75, 5.30)	(1.89, 3.48)	(1.57, 2.83)^*	<0.001	99.0
Platelet count (x10⁹/L)	140.0–400.0	18	1927	174.81	6917	212.04	-36.06	-1.37	<0.001	97.7
Platelet count (x10⁹/L)	140.0–400.0	18	1927	(162.65, 186.96)	6917	(200.81, 223.28)	(-49.34, -22.77)	(-1.78, -0.95)^*	<0.001	97.7
Haemoglobin (g/L)	Men 140–170	16	1096	127.56	8798	130.84	-3.47	-0.41	0.018	97.2
Haemoglobin (g/L)	Women 120–150	16	1096	(125.83, 129.28)	8798	(127.91, 133.76)	(-5.84, -1.09)	(-0.75, -0.07)^*	0.018	97.2
Coagulation
D-dimer (mg/L)	0–0.5	27	2460	4.17	8804	0.91	3.22	1.76	<0.001	97.6
D-dimer (mg/L)	0–0.5	27	2460	(3.65, 4.70)	8804	(0.73, 1.09)	(2.84, 3.61)	(1.39, 2.13)^*	<0.001	97.6
Prothrombin time (s)	10.0–14.0	11	626	12.66	2345	11.67	0.93	1.35	<0.001	97.2
Prothrombin time (s)	10.0–14.0	11	626	(7.92, 17.40)	2345	(7.54, 15.80)	(0.45, 1.40)	(0.73, 1.97)^*	<0.001	97.2
APTT (s)	30–40	10	671	34.17	2020	33.50	0.79	0.28	0.112	91.9
APTT (s)	30–40	10	671	(31.38, 36.97)	2020	(30.58, 36.42)	(-0.13, 1.71)	(-0.07, 0.63)	0.112	91.9
Liver function/aggression
Albumin (g/L)	3.5–5.5	17	1145	29.50	7222	34.20	-4.70	-2.63	<0.001	99.0
Albumin (g/L)	3.5–5.5	17	1145	(26.24, 32.76)	7222	(31.15, 37.26)	(-6.14, -3.26)	(-3.45, -1.80)^*	<0.001	99.0
Total bilirubin (mmol/L)	3.0–22.0	10	618	10.72	1908	8.97	1.86	0.79	<0.001	94.5
Total bilirubin (mmol/L)	3.0–22.0	10	618	(6.29, 15.15)	1908	(6.64, 11.29)	(0.93, 2.78)	(0.34, 1.24)^*	<0.001	94.5
AST (U/L)	14.0–36.0	21	2098	49.53	9518	34.43	17.41	1.61	<0.001	97.5
AST (U/L)	14.0–36.0	21	2098	(45.36, 53.69)	9518	(31.50, 37.36)	(13.99, 20.83)	(1.22, 2.00)^*	<0.001	97.5
ALT (U/L)	9.0–52.0	25	2373	32.45	10542	30.16	2.18	0.44	<0.001	96.3
ALT (U/L)	9.0–52.0	25	2373	(30.18, 34.72)	10542	(27.97, 32.34)	(0.09, 4.28)	(0.39, 0.49)^*	<0.001	96.3
Kidney function
Urea nitrogen (mmol/L)	2.5–6.1	14	798	12.06	3737	5.80	6.64	2.43	<0.001	96.7
Urea nitrogen (mmol/L)	2.5–6.1	14	798	(10.33, 13.79)	3737	(5.31, 6.29)	(5.19, 8.09)	(1.90, 2.97)^*	<0.001	96.7
Creatinine (μmmol/L)	46.0–92.0	21	1442	90.09	8173	68.33	21.72	1.28	<0.001	96.8
Creatinine (μmmol/L)	46.0–92.0	21	1442	(66.44, 113.74)	8173	(48.74, 87.92)	(16.72, 26.71)	(0.97, 1.59)^*	<0.001	96.8
Inflammatory factors
CRP (mg/L)	0.5–10.0	30	3322	133.18	13338	64.39	68.31	2.49	<0.001	98.9
CRP (mg/L)	0.5–10.0	30	3322	(112.77, 153.59)	13338	(54.96, 73.82)	(53.11, 83.50)	(2.01, 2.96)^*	<0.001	98.9
Interleukin-6 (pg/mL)	0–7	12	1734	73.87	5735	29.88	43.64	2.31	<0.001	99.1
Interleukin-6 (pg/mL)	0–7	12	1734	(57.99, 89.76)	5735	(25.08, 34.68)	(30.92, 56.35)	(1.47, 3.15)^*	<0.001	99.1
LDH (U/L)	140.0–280.0	19	2230	506.89	9667	328.02	180.26	2.21	<0.001	98.5
LDH (U/L)	140.0–280.0	19	2230	(336.59, 677.18)	9667	(216.07, 439.97)	(131.02, 229.51)	(1.70, 2.72)^*	<0.001	98.5
Procalcitonin (ng/mL)	0–0.15	18	2045	0.63	6367	0.16	0.52	1.58	<0.001	97.9
Procalcitonin (ng/mL)	0–0.15	18	2045	(0.52, 0.74)	6367	(0.13, 0.19)	(0.42, 0.62)	(1.14, 2.02)^*	<0.001	97.9
Ferritin (ng/L)	Men 24–336	13	1663	1396.19	4404	797.98	603.94	1.56	<0.001	98.2
Ferritin (ng/L)	Women 11–307	13	1663	(1229.84, 1562.55)	4404	(685.52, 910.44)	(383.27, 824.60)	(1.00, 2.12)^*	<0.001	98.2
Cardiac troponin-I (ng/mL)	0–0.04	15	1161	0.05	3852	0.07	0.02	0.91	0.022	98.9
Cardiac troponin-I (ng/mL)	0–0.04	15	1161	(0.05, 0.06)	3852	(0.04, 0.10)	(0.02, 0.02)	(0.13, 1.70)^*	0.022	98.9
ESR (mm/h)	0–15	6	358	57.15	1369	48.12	9.57	0.34	<0.001	91.5
ESR (mm/h)	0–15	6	358	(32.28, 82.02)	1369	(35.05, 61.19)	(1.75, 17.39)	(0.22, 0.47)^*	<0.001	91.5

* p-value <0.05.

ALT: alanine transaminase; APTT: activated partial thromboplastin time, AST: aspartate transaminase; BMI: body mass index; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate, LDH: lactate dehydrogenase.