Fig 3. Recruited monocyte-derived macrophages are polarized to a profibrotic phenotype.

Tree shrews were exposed to saline (n = 3) or bleomycin (n = 3) and BAL cells were isolated. FACS-sorted RAMs and MDMs were analyzed for (A) arginase 1, (B) VEGF, (C) TGF-β, (D) PDGF-B, (E) iNOS, and (F) TNF-α mRNA expression. ***, p < 0.0001. Values shown as mean ± S.E.M. One-way ANOVA with Tukey post-test was utilized.