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. 2020 Nov 3;15(11):e0241323. doi: 10.1371/journal.pone.0241323

Fig 4. Macrophage-derived profibrotic gene expression regulates fibroblast differentiation.

Fig 4

(A) Immunoblot analysis of IPF fibroblasts cultured in BAL fluid from saline- (n = 3) or bleomycin-exposed (n = 3) tree shrews. (B) Quantification of α-SMA expression in A (n = 3 per group). mRNA analysis of (C) collagen 1a and (D) fibronectin in IPF fibroblasts cultured in BAL fluid from saline- (n = 3) or bleomycin-exposed (n = 3) tree shrews. **, p < 0.001; ***, p < 0.0001. Values shown as mean ± S.E.M. Two-tailed t-test statistical analysis was utilized.