Table 3. PAE in sessile S. pneumoniae strains forming biofilms after 1 h exposure to drug, measured by viable count method.
| Strain | PAE (h ± SD)a | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| LVX (× MIC) | MXF (× MIC) | SCN (× MIC) | |||||||
| 1 | 2.5 | 5 | 1 | 2.5 | 5 | 1 | 2.5 | 5 | |
| R6 | 0.99 ± 0.16 | 2.23 ± 0.10 | 3.32 ± 0.03 | 0.89 ± 0.18 | 1.20 ± 0.21 | 1.91 ± 0.24 | 0.84 ± 0.09 | 1.26 ± 0.08 | 2.31 ± 0.36 |
| T2 | 1.21 ± 0.18 | 1.57 ± 0.27* | 1.89 ± 0.37* | 0.25 ± 0.17* | 0.76 ± 0.13* | 1.34 ± 0.15* | 0.76 ± 0.12◻ | 1.53 ± 0.19◻ | 2.47 ± 0.07◻♦ |
a PAE values, considered significant (≥ 0.5 h) are indicated in boldface. Results are the average ± SD of three independent replicates. Significant differences in PAE values (P < 0.05)
♦ longer with SCN than with LVX at similar concentration in the same strain
◻ longer with SCN than with MXF at similar concentration in the same strain
* shorter in the HL-R strain T2 than in the S strain R6.