Figure 3.

High Cdh6 expression is persistent in the Hnf4a mutant kidney. (A) In the P0 control kidney, Cdh6 expression is high in LTL^neg and LTL^low, presumptive proximal tubule (PT) cells (red and orange arrowheads, respectively), and Cdh6 expression decreases as PT cells develop into LTL^high, mature PT cells (yellow arrowheads). In the Hnf4a mutant kidney, Cdh6^high, LTL^low cells are more abundant compared with the control, and there are no Cdh6^low, LTL^high cells to be found. Image is representative of n=3. Scale bar, 100 μm. (B) Quantification of Cdh6^high and Cdh6^low cells in the Hnf4a mutant and control kidney. *P<0.01 determined by t test.