Table 3.

Clinical description of included patients with poisoning

Parameters	Chloroquine, 12 patients	Hydroxychloroquine, 1 patient	Quinine, 25 patients
Patient characteristics
Median age, yr	25.5	33	23
Men, %	33.3	0	44
Poisoning information
Median dose, g	8.4	30	6.0
Median time from ingestion to admission, h	1.5	3.0	3.5
Median plasma concentration, mg/L	4.7 (p), 19 (b)a	uncertainb	15.1
Signs/symptoms/laboratory
Coma, %	60	100	42
Visual impairment, %	28	0	87
Hypotension, %	83	100	28
Respiratory depression, %	82	100	21
Severe dysrhythmia/cardiac arrest, %	64	100	21
Auditory impairment, %	0	0	88
AKI, %	20	100	29
Median potassium, mmol/L	2.6	3.0	4.0
Prolonged QRS complex duration, %	80	100	7
Median QRS complex duration, ms	140	140	110
Prolonged QT interval, %	83	100	23
Median QT interval, ms	490	576	420
Other treatments, %
Gastric lavage	70	100	69
Activated charcoal	78	100	6
Benzodiazepines	71	100	0.6
Bilateral stellate ganglion block	0	0	33
Cardiac pacing	10	100	6
Mechanical ventilation	75	100	25
Vasopressors	86	100	31
ECTR, n
Hemodialysis	0	100	7
Hemoperfusion	8		5
Exchange transfusion	0		5
Hemoperfusion and hemodialysis in series	2		1
Peritoneal dialysis	2		5
>1 ECTR used	0		2
Outcome
Visual sequelae, %	0	0	26
Median LOS, d	11	6 (ICU)	13
Death, %	42	0	12

Percentages are on the basis of available data (if the data are not shown, they are removed). p, plasma; b, blood; LOS, length of stay ICU, intensive care unit.

^aBlood concentration can estimated to be approximately four times as high as the plasma concentration.^6,69

^bPlasma concentration stated in the article was 6425 mol/L, likely an error.