(A) Mechanisms of CRISPRi/a-based gene expression control. The activity of ‘helper’ effector domains is required except for bacterial and yeast CRISPRi, where dCas9 alone can efficiently repress gene expression by interfering with transcription initiation or elongation. These effector domains can be either fused to dCas9 or recruited through an additional RNA-recognizing domain that binds to a specific extension of the gRNA. (B) Strategies to modulate CRISPRi/a activity. CRISPR gene control has proved a versatile platform that tolerates numerous engineering extensions. Due to its dual protein-RNA nature, the activity of the dCas9-gRNA complex can be modulated at the level of the protein (dCas9), at the level of the gRNA, or at the interface between the two. Note that for simplicity this panel depicts dCas9 alone, but many of these tuning strategies actually also work with dCas9 fused to effectors.