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. 2020 Sep 11;48(5):2213–2227. doi: 10.1042/BST20200468

Figure 6. RhoC activation of STAT3 in cancer.

Figure 6.

(A) RhoC can stimulate IL-6 production in HNSCC cell lines, possibly via NF-κB activation, which allows for autocrine STAT3 activation via the IL-6R/JAK. Phosphorylated, activated STAT3 can then stimulate transcription of key transcription factors needed for cancer stem cell ‘stemness’. (B) RhoC is overexpressed in gastric cancer which increases STAT3 activation. Gastric cancer cells have low expression of the RhoC E3 ligase, RNF180, and thus increased expression of such ligase could help drive RhoC ubiquitination and proteasomal degradation, thus blocking STAT3 activation.