Table 1. Biological processes involving the Rac1/STAT3 signalling axis.

Biological process	Description
Mammary gland involution	Death of epithelial cells after lactation. Rac1 and DOCK1 required for timely activation of STAT3, which triggers the start of involution and the activation of cell death pathways [30].
Psoriasis	Epidermal dysfunction disorder. Patients have elevated active Rac1 and consequently increased STAT3 activation [31].
Chondrogenesis	Development of cartilage. Rac1 driven STAT3 activation is required for this process [32].
Mammalian primordial follicle pool production	Pool production controls mammalian female reproductive abilities. Rac1 driven STAT3 activation is required for transcription of genes such as Jagged1, BMP15, GDF9 and Nobox [33].