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. 2020 Sep 14;161(12):bqaa164. doi: 10.1210/endocr/bqaa164

Figure 6.

Figure 6.

Cortex gene expression is altered by in utero exposure to bisphenol A (BPA), as verified by qPCR. A: Representative genes that are upregulated in the in utero BPA-treated male and female mice, including Ttr, Adora2a, Drd2, KL, Ptgs2, Rgs4, and Enpp2 (Ttr: P < 0.0001 and P = 0.02, males and females, respectively; Adora2a: P = 0.02, male; Drd2: P = 0.006, male; KL: P = 0.04, male; Ptgs2: P = 0.009, female; Rgs4: P = 0.05, female; Enpp2: P = 0.05 and P < 0.0001, males and females, respectively). B: Representative genes that are downregulated in the in utero BPA-treated male and female mice, including Gfra2, Ighm, Zic1, Fat2, and Lcn2 (Gfra2: P = 0.04, male; Ighm: P = 0.03, male; Zic1: P = 0.001, female; Fat2: P = 0.03, female; Lcn2: P = 0.004, female). C: Representative genes that are differentially regulated in the in utero BPA-treated male versus female mice, including Prkcd, Kcnh7, and Lrp11 (Prkcd: P = 0.002 and P = 0.04; Kcnh7: P = 0.17 and P = 0.35, Lrp11: P = 0.47 and P = 0.22, males and females, respectively). Bars: mean + standard error of the mean (SEM) of the results; * P < 0.05, ** P < 0.01, **** P < 0.0001 (unpaired 2-tailed Student’s t-test), N = 14. Abbreviation: CT, control.