Table 3. Ag-mediated regulation of host cell necrosis.

Proteins/Ag	Experimental model	Mechanism of action	Effects	Ref.
ESAT-6	Human neutrophils	Ca2+ mediated calpain activation	NETosis	(94)
PPE11	THP-1 cells, in vivo studies	Imbalance of pro-inflammatory and anti-inflammatory cytokines	Establishment of a persistent infection	(102)
PE17	Mouse peritoneal macrophages, in vivo studies	Nuclear damage, loss of cytoplasmic membrane integrity, reduction of pro-inflammatory cytokines	Enhance bacterial survival and bacterial burden in mice	(103)