Figure 6. Schematic draw of SARS-CoV2 genome and spike gene. NCBI (accession number: NC_045512) of 29,903 bp SARS-CoV2 genome was depicted physical map in genetics according to twelve ORF gene with poly^+A sequence. The third ORF spike gene containing 3,822 bp codes 1,273 amino acid residues including “TAA” stop codon. The spike gene was shown by green bar expanded for sixteens subdomains with or without function. S1 and S2 subdomain cleavage site was indicated by blue letter (R685). The specific mutation sites were indicated by black line with red letter.

SP, signal peptide; NTD, N-terminal domain; L1, loop 1; RBD, receptor binding domain; L2, loop 2; FP, fusion peptide; CR, connected region; HR, heptad repeat; CH, central helix; BH, b-hairpin; TM, transmembrane domain; CT, cytosolic domain.