Table 2.
Comparison of clinical and laboratory parameters between COVID-19 patients with acute cardiac injury and those without acute cardiac injury.
| Acute cardiac injury present (n = 28) | Acute cardiac injury absent (n = 80) | P-value | |
|---|---|---|---|
| Age (years) | 60.9 ± 15.1 | 47.9 ± 17.4 | 0.001 |
| Sex (M/F) | 14/14 (50%/50%) | 56/24 (70%/30%) | 0.06 |
| Duration of symptoms (in days) | 4.4 ± 3.1 | 3.9 ± 2.1 | 0.31 |
| Presence of co-morbidities | 23 (82.1%) | 37 (46.3%) | 0.001 |
| Hypertension | 18 (64.3%) | 23 (30%) | <0.0001 |
| Diabetes | 20 (71.4%) | 15 (18.6%) | 0.005 |
| Cardiovascular disease | 7 (25%) | 7 (8.7%) | 0.03 |
| Heart Rate (per min) | 94.4 ± 16.4 | 88.2 ± 14.1 | 0.06 |
| Systolic blood pressure (mmHg) | 118.5 ± 23.2 | 122.9 ± 17.5 | 0.29 |
| Haemoglobin (gm/dl) | 12.2 ± 2.9 | 12.8 ± 2.2 | 0.29 |
| Total leucocyte count (per mm3) | 10430.4 ± 5640.9 | 8195.8 ± 5062.4 | 0.05 |
| Lymphopenia | 8 (28.6%) | 27 (33.7%) | 0.61 |
| Platelet count (105/mL) | 1.79 ± 0.87 | 2.17 ± 0.84 | 0.04 |
| Aspartate aminotransferase (U/L) | 177.7 ± 445.4 | 37.5 ± 30.3 | 0.006 |
| Alanine aminotransferase (U/L) | 114.1 ± 312.6 | 31.1 ± 25.1 | 0.02 |
| Serum urea (mg/dl) | 58.4 ± 40.9 | 34.8 ± 31.6 | 0.002 |
| Serum creatinine (mg/dl) | 2.1 ± 2.1 | 1.3 ± 1.4 | 0.03 |
| Delta QTc (milliseconds) | 26.1 ± 19.8 | 25.9 ± 27 | 0.96 |
| Maximum QTc (milliseconds) | 453.37 ± 32.7 | 441.5 ± 39.1 | 0.15 |
| ST-T changes on ECG | 9 (32.1%) | 7 (8.7%) | 0.01 |
| Tisdale QT score | 8.96 ± 2.98 | 6.34 ± 2.70 | <0.0001 |
| CK-MB (U/L) | 55.7 ± 30.1 | 23.8 ± 7.9 | <0.0001 |
| Troponin-T (μg/L) | 0.66 ± 1.28 | 0.01 ± 0.0008 | 0.001 |
| D-dimer positivitya | 16/19 (84.2%) | 22/60 (36.6%) | <0.0001 |
| Serum LDH (U/L) | 1403 ± 1491.8 | 661.8 ± 298.8 | 0.002 |
| VT/VF | 0/78 (0%) | 2/30 (6.67%) | 0.02 |
| SOFA score | 5.21 ± 3.03 | 1.98 ± 2.30 | <0.0001 |
| Mortality | 16 (57.1%) | 14 (17.5%) | <0.0001 |
CK-MB: creatine kinase myocardial band; CRP: C-reactive protein; ECG: electrocardiogram; F: female; gm/dl: gram per deciliter; LDH: Lactate dehydrogenase; M: male; μg/L: microgram per litre; mg/dl: milligram per deciliter; mL: milliliter; SOFA: sequential organ function assessment; U/L: units per liter; VT/VF: ventricular tachycardia/ventricular fibrillation.
A P-value ≤0.05 was considered as statistically significant (highlighted in bold).
a
Done in 79 patients.