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. 2020 Nov 4;86:104616. doi: 10.1016/j.meegid.2020.104616

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© 2020 Published by Elsevier B.V.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 1 — Regional comparative genomic analysis of SARS-CoV-2. A. Geographical distribution of the sequences from Venezuelan genomes and the available Colombian genomes analyzed in this study. The pink symbols indicate the Venezuelan patients identified in Colombia with their respective Venezuelan state origin. B. Stacked bar plot of the number of genomes per lineage determined using Phylogenetic Assignment of Named Global Outbreak LINeages ‘Pangolin’ tool. Three SARS-CoV-2 genomes from Venezuela were compared with 376 assemblies from other 7 South American countries (Argentina, Brazil, Chile, Colombia, Ecuador, Peru and Uruguay) using the publicly available GISAID EpiCoV™ database (https://www.gisaid.org/). Frequencies are discriminated by country of origin. The Venezuelan lineages are identified by black arrows. C. Maximum likelihood tree built in IQtree shows the phylogenetic relationships between genomes from Venezuela (pink dots) and the closest Colombian regions (yellow dots) with other South American genomes. The branches were colored according to the country of origin, using the color code of A panel. The clustering of the most frequent pangolin lineages (n > 10) is represented on the right side. The black dots represent highly supported nodes. D. Multiple alignment of the Nucleocapsid gene showing the substitutions found using the Wuhan-1 sequence as reference.