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. Author manuscript; available in PMC: 2021 Aug 12.
Published in final edited form as: Nano Lett. 2020 Jul 31;20(8):6170–6175. doi: 10.1021/acs.nanolett.0c02536

Figure 4. CpG-constructs that form a high percentage of hollow endosomes also result in enhanced IS activity.

Figure 4.

(a) Alkaline phosphatase (AP) and (b) cytokine secretion of macrophages after a 24 h treatment with CpG-constructs at varied CpG densities and surface curvatures. The results indicate that CpG-density changes the IS activity of constructs with mixed curvatures, but not with constant curvature. Error bars were from six independent experiments. ([CpG] = 200 nM, 24 h incubation)