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. 2020 Nov 3;20(6):559–570. doi: 10.1007/s40256-020-00446-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 2 — Interactions between antithrombotic drugs and agents used for COVID-19. White: no data; green: no interaction; yellow: minor interaction, possibly requiring dose reduction of DOACs, additional INR controls (if VKA therapy) or functional monitoring of antiplatelet activity (in the case of P2Y₁₂ treatment); red: co-administration is contraindicated because of significant interaction. Upward arrows: increased activity of the antithrombotic drug, proportional to the number of arrows; downward arrows: decreased activity of the antithrombotic drug, proportional to the number of arrows. Adapted from ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic (https://www.escardio.org/Education/COVID-19-and-Cardiology/ESC-COVID-19-Guidance). COVID-19 coronavirus disease 2019, CV cardiovascular, DOAC direct oral anticoagulant, ESC European Society of Cardiology, INR international normalized ratio, UFH unfractionated heparin, VKA vitamin K antagonist anticoagulant