Table 1.

Kinetic and equilibrium dissociation constants for the binding of RAP to immobilized ecto-LRP1 and clusters II, III, and IV.

	ka (M−1 s−1)	kd (s−1)	KD (nM)	na
Immobilized ecto LRP1	1.41 ± 0.17 × 106	1.05 ± 0.07 × 10−3	0.76 ± 0.08	4
Immobilized cluster II	2.20 ± 1.42 × 106	1.96 ± 0.86 × 10−3	1.09 ± 0.31	2
Immobilized cluster III	2.95 ± 0.37 × 106	3.08 ± 0.09 × 10−3	1.06 ± 0.10	2
Immobilized cluster IV	1.18 ± 0.40 × 106	1.47 ± 0.37 × 10−3	1.28 ± 0.12	2

Values are expressed as means ± SE.

n^a Number of separate experiments.