Fig.1. Mobility and motor coordination in multiple mouse strains and genotypes.
A. Open field testing was performed for 15 min on sets of 3 nontransgenic strains plus 3xTG-H mice at 3, 6 and 9 months of age. B,C&D. Rotarod testing was performed on the same sets of mice as in A at the same ages. Open field and rotarod testing, followed by 5 days without handling, was always performed before animals were subjected to Barnes Maze acclimatization, training and testing. Results of significant paired t-tests are shown; NS, not significant; data are mean + s.e.m. Color code: C57, white diamonds; 3xTG-H, red boxes; B6129, green circles.