Table II:
Change in Geriatric Domains over a period of 6-months (median, range)
| Characteristic | N (baseline, 6 months) | Baseline | 6 months | Change Baseline to 6 months | P-value |
|---|---|---|---|---|---|
| Body Mass Index (kg/m2) | 40, 34 | 29.4 (16.3,39.3) | 27.3 (18.5,42.4) | −0.5 (−6.9,3.8) | 0.36‡ |
| Karnofsky performance status | 40, 33 | 80 (50,100) | 80 (40,100) | 0 (−30,40) | 0.15‡ |
| Number of Medications | 39, 28 | 9 (1,23) | 9 (4,25) | 1 (−6,18) | 0.54‡ |
| Number of dependent IADL domains | 40, 36 | 2 (0,11) | 1 (0,8) | 0 (−5,6) | 0.83‡ |
| Psychological status: Mental Health Inventory-17 Total Score | 40, 34 | 77.1 (31.8,96.5) | 84.3 (53.9,100) | 6.0(−19.0,53.9) | <0.001‡ |
| Cognition: Blessed Orientation Memory Concentration Test Score | 40, 34 | 2 (0,22) | 1 (0,14) | 0 (−8,8) | 0.22‡ |
| Medical Outcomes Study | |||||
| Patient limited in moderate activity (N, %) | 40, 36 | 0.73†* | |||
| Not at all | 11 (27.5%) | 11 (30.5%) | |||
| Limited a little | 10 (25.0%) | 10 (27.7%) | |||
| Limited a lot | 19 (47.5%) | 15 (41.6%) | |||
| Improved / Stable at 6 months | 32 (88.9%) | ||||
| Worsening at 6 months | 4 (11.1%) | ||||
| Number of falls (N,%) | 0.39† | ||||
| 0 | 39, 35 | 28 (71.8%) | 29 (82.9%) | ||
| 1 or more | 11 (28.2%) | 6 (17.1%) | |||
| 0 falls baseline / 0 6 months | 20 (58.8%) | ||||
| 0 falls baseline / 1+ 6 months | 4 (11.8%) | ||||
| 1+ falls baseline / 0 6 months | 8 (23.5%) | ||||
| 1+ baseline / 1+ 6 months | 2 (5.7%) | ||||
| Timed Up and Go Test#, seconds | 35, 28 | 12.3 (7.3–33.5) | 11.0 (6.2–23.4) | −0.7 (−10.2, 2.7) | 0.057‡ |
IADL Instrumental Activity of Daily Living
†
McNemar test comparing Not at all vs At least some limitation, or 0 vs 1+ falls
‡
Wilcoxon rank sum test of whether the change score compared to baseline equals 0
*
based on not at all versus limited a little/lot
#
Calculated only for patients able to complete the Timed Up and Go Test unassisted