Table 1.
Potential Anti-Covid-19 Therapeutic Treatments.
| PHASES AND SYMPTOMS | THERAPEUTIC TARGETS | THERAPEUTIC INTERVENTIONS |
|---|---|---|
|
1) VIRAL PHASE (about 1–5° days) Inflammation of first air ducts and eyes (rhinitis, pharyngitis, conjunctivitis). Inflammation of middle air tracts (tracheitis, bronchitis, fever, cough) |
- Blocking inflammation factors and histamine (amplifying inflammatory effects) - Neutralizing the virus for preventing its replication and a consequent Ag excess condition |
- Anti-inflammation drugs - Anti-histamine drugs - Anti-Spike (RBD, NTD) mFabs |
|
2) IMMUNOLOGICAL PHASE (about 6–10° days) Inflammation of the lower air tracts and pulmonary alveoli, dyspnea, tissue and vascular C-mediated lesions |
- Blocking the IC formation by neutralization of the viral Ags without involving the C system - Blocking the complement cascade activation and its systemic effects |
-Anti-spike(RBD) mFabs or -Anti-spike(RBD) micro-Abs - C1 INH (inhibitor of C1), already in use as a drug for hereditary angioedema and other extravasation diseases |
|
3) HEMO-VASCULAR PHASE (about 11–15° days and more) Tissue and vascular lesions, thrombus formation, extravasation (interstitial pneumonia, renal, heart, brain, and skin damages) |
- Preventing platelet aggregation and activation - Blocking the fibrin synthesis process -Dissolving the systemic micro- vascular thrombi |
- Acetyl salicylic acid - Anti-histamine drugs - Anti-coagulant drugs - Fibrin-lytic agents |