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. 2020 Oct 21;11:566000. doi: 10.3389/fimmu.2020.566000

Table 1.

Potential Anti-Covid-19 Therapeutic Treatments.

PHASES AND SYMPTOMS THERAPEUTIC TARGETS THERAPEUTIC INTERVENTIONS
1) VIRAL PHASE      (about 1–5° days)
Inflammation of first air ducts and eyes (rhinitis, pharyngitis, conjunctivitis). Inflammation of middle air tracts (tracheitis, bronchitis, fever, cough)
- Blocking inflammation factors    
and histamine (amplifying inflammatory effects)
- Neutralizing the virus for preventing its replication and a consequent Ag excess condition
- Anti-inflammation drugs         - Anti-histamine drugs
- Anti-Spike (RBD, NTD) mFabs
2) IMMUNOLOGICAL PHASE (about 6–10° days)
Inflammation of the lower air tracts and pulmonary alveoli, dyspnea, tissue and vascular C-mediated lesions
- Blocking the IC formation by neutralization of the viral Ags without involving the C system           
- Blocking the complement cascade activation and its systemic effects
-Anti-spike(RBD) mFabs
 or
-Anti-spike(RBD) micro-Abs
- C1 INH (inhibitor of C1), already in use as a drug for hereditary angioedema and other extravasation diseases
3) HEMO-VASCULAR PHASE (about 11–15° days and more)    
Tissue and vascular lesions, thrombus formation, extravasation (interstitial pneumonia, renal, heart, brain, and skin damages)
- Preventing platelet aggregation
and activation
- Blocking the fibrin synthesis process   
-Dissolving the systemic micro- vascular thrombi    
- Acetyl salicylic acid    - Anti-histamine drugs
- Anti-coagulant drugs   
- Fibrin-lytic agents