Fig. 5.

The ERK1/2 activator reversed effects of Met-RANTES on neurobehavioral outcomes after ICH and TPR1 CRISPR abolished the pro-inflammatory effects of rCCL5 and improved neurological function. a Modified Garcia test, (b) forelimb placement test, (c) corner turn test, and (d) the effects of Met-RANTES on body weight loss at 24 h after ICH. *p < 0.05 versus sham, #p < 0.05 versus ICH + vehicle, @p < 0.05 versus ICH + Met-R + Vehicle, and &p < 0.05 versus Naive +Vehicle, %p < 0.05 versus Naive + rCCL5 + scr CRISPR. Error bars are represented as mean ± SD. One-way ANOVA, Tukey’s test, n = 6 per group