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. 2020 Nov 3;11:5553. doi: 10.1038/s41467-020-19426-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Charts represent the proportion of individuals inheriting the Reckh drive element (GFP⁺, in green) from heterozygous parents originating from drive males or drive females. The proportions of individuals that have not inherited the drive (GFP⁻) element and have WT black eyes (kh⁺) (dark grey) and those with white (kh⁻) or mosaic (kh^mos) eyes (light grey) are also shown. Rare (n = 2) drive individuals with mosaic eyes (GFP⁺/kh^mos) are depicted in light green. “H” and “h” refer to the mosquito genome at the kh locus, where “H” is the Reckh drive allele and “h” is a non-drive allele. The green arrows show the potential for conversion of the h allele in the germline. The corresponding HDR rate, i.e., the proportion of h alleles converted to H alleles is reported. Each cross was performed en masse (30 females and 15 males) in triplicate cages using drive individuals mated to WT and by screening a representative subset of individuals (n) generated in the progeny. The numbers reported are pooled from the three replicate cages. Raw data for these crosses are reported in Supplementary Table 2. Data on transmission and HDR rates reported in the “Results” section refer to the averages of progeny from both mothers and fathers originating from a male or a female drive individual.