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. 2020 Nov 3;10:18923. doi: 10.1038/s41598-020-75014-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental design. (a) Manual collection of articles to analyze the relationship between the numbers of different types of misfolded proteins accumulated in the nervous system and neurodegenerative diseases (NDs). (b) Brain autopsies collection from HUB-ICO-IDIBELL biobank, Spain, to analyze the dynamics of the brain multimorbidity with the advance of age. (c) Automatic search with our Big-data software of age-stratified incidence data articles and manual curation and data extraction for building of the NDs tree. The flow diagram follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-style guidelines⁵¹.