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. 2020 Nov 3;10:18923. doi: 10.1038/s41598-020-75014-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Tree of the genealogy of the neurodegenerative diseases (NDs). The tree shows the number of steps necessary for a ND to occur. The common steps are represented by the trunk of the tree and the non-common, specific steps, by the branches of the tree. The left and right tree sides depict the specific branches of the male and female NDs, NDm and NDf, respectively. The red rings mark the branch-out points. Red, blue and green ellipses mark the stem-, trunk- and crown-associated NDs, respectively. NDs: Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Fronto Temporal Dementia (FTD), Dementia with Lewy Bodies (DLB), Parkinsonism (PDM), Parkinson’s Disease with Dementia (PDD), Creutzfeldt–Jakob disease (CJD), Multiple Sclerosis (MS).