Table 3.
Linear regression models for the effect of BPS on FEV1 (% predicted), RV/TLC (% predicted) at baseline, or FEV1 change (% predicted) after intramuscular triamcinolone acetonide (TA) administration
FEV1 (% predicted) | RV/TLC (% predicted) | FEV1 (% predicted) change after TA | ||||
---|---|---|---|---|---|---|
Model | β (95% CI) | p | β (95% CI) | p | β (95% CI) | p |
Unadjusted | −6.1 (−10.4, −1.8) | 0.007 | 6.0 (2.2, 9.9) | 0.003 | −1.4 (−3.5, 0.6) | 0.17 |
Adj. for age and severity | −6.1 (−9.9, −2.2) | 0.003 | 5.7 (1.9, 9.5) | 0.004 | −1.8 (−3.8, 0.2) | 0.09 |
Adj. for age, severity, FEV1 | - | 1.2 (−1.5, 3.8) | 0.40 | −2.6 (−4.6, −0.4) | 0.02 |
β estimate for the association with BPS showing the amount of difference in a lung function variable or in the FEV1 change variable that would be expected for a 1 SD (15 ng/ml) increase in BPS, n = 62 (with complete RV/TLC data) for FEV1 and RV/TLC, 55 for FEV1 change. FEV1 = pre-bronchodilation FEV1. With n = 70, β was −6.9 (−11.3, −2.5), p = 0.002, for FEV1. Adj., adjusted; BPS, baseline P-selectin; CI, confidence interval; FEV1, forced expiratory volume in 1 s; rs, Spearman rank correlation coefficient; RV, residual volume; TLC, total lung capacity.