Table 3.
Areas of significant connectivity for the memory and default mode network (DMN) correlating positively with episodic memory function in age-related macular degeneration (AMD) compared to control participants and in AMD participants alone*, controlling for age and years of education.
| Cluster regions | Brodmann Area | size (voxels) | max Z | MNI Coordinates | ||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| Memory Network | ||||||
| Seed region: LPHC | ||||||
| AMD - Control | ||||||
| L MTG, TP, ITG | 21,38 | 360 | 4.22 | −54 | 8 | −28 |
| R IFG, MFG, SFG** | 45,9,46 | 850 | 4 | 50 | 34 | 14 |
| AMD | ||||||
| R TP, MTG, ITG | 20,21,38 | 668 | 5.17 | 40 | 14 | −40 |
| L SFG, MFG, IFG | 45,48 | 1338 | 4.36 | −34 | 66 | 0 |
| R MFG, SFG, SMFG | 9,10,45,46 | 1819 | 4.28 | 28 | 46 | 38 |
| L MTG, AG, I PL | 39,40 | 473 | 4.06 | −54 | −70 | 24 |
| L SMFG*** | 8,9,10 | 398 | 3.87 | −8 | 46 | 48 |
| DMN | ||||||
| Seed region: mPFC | ||||||
| AMD - Control | ||||||
| L/R Precuneus, L PCC, MCC, R Calcarine**** | 30,23,17 | 397 | 3.65 | −12 | −52 | 22 |
| AMD | ||||||
| L/R Precuneus, PCC, calcarine | 30,23,26 | 870 | 4.84 | −14 | −50 | 26 |
| R AG, MTG, SPL, MPL, SOG, MOG***** | 39,19,7 | 489 | 4.49 | 54 | −62 | 40 |
Threshold: p < 0.005, voxel-level uncorrected, and p < 0.05, cluster-level corrected
LPHC: left parahippocampal cortex, MTG: middle temporal gyrus, TP: temporal pole, ITG: inferior temporal gyrus, IFG: inferior frontal gyrus, MFG: middle frontal gyrus, SFG: superior frontal gyrus
SMFG: superior medial frontal gyrus, AG: angular gyrus, IPL: inferior parietal lobule
PCC: posterior cingulate cortex, MCC: middle cingulate cortex
SPL: superior parietal lobule, MPL: middle parietal lobule, MOG: middle occipital gyrus, SOG: superior occipital gyrus