Table 3:

Microbiome diversity measurements between baseline and follow-up based on expanded quantitative urine culture results

	Baseline, Adjusted mean (SE)	Follow-up, Adjusted mean (SE)	Change, Adjusted mean (SE)	p-value
	Catheterized urine samples
Shannon index	0.83 (0.12)	0.65 (0.12)	−0.17 (0.16)	0.30
Simpson index	0.49 (0.06)	0.49 (0.06)	0.00 (0.09)	0.97
Species richness	3.94 (0.49)	3.41 (0.48)	−0.53 (0.66)	0.43
Pielou’s evenness	0.65 (0.07)	0.57 (0.07)	−0.09 (0.10)	0.39
% Lactobacillus	10.8 (5.4)	25.1 (5.3)	14.4 (6.6)	0.037
	Vaginal swab samples
Shannon index	1.29 (0.08)	1.04 (0.08)	−0.25 (0.12)	0.047
Simpson index	0.61 (0.04)	0.54 (0.04)	−0.07 (0.05)	0.19
Species richness	8.83 (0.52)	7.36 (0.52)	−1.46 (0.70)	0.043
Pielou’s evenness	0.62 (0.03)	0.56 (0.03)	−0.06 (0.05)	0.21
% Lactobacillus	17.7 (5.2)	24.2 (5.1)	6.6 (6.6)	0.33
	Perineal swab samples
Shannon index	1.37 (0.09)	1.46 (0.09)	0.08 (0.11)	0.47
Simpson index	0.65 (0.03)	0.71 (0.03)	0.06 (0.04)	0.15
Species richness	9.66 (0.58)	8.30 (0.56)	−1.36 (0.72)	0.07
Pielou’s evenness	0.60 (0.04)	0.71 (0.04)	0.10 (0.05)	0.034
% Lactobacillus	6.7 (3.1)	9.2 (3.0)	2.5 (4.2)	0.56
	Voided urine samples
Shannon index	1.10 (0.11)	0.99 (0.10)	−0.12 (0.15)	0.45
Simpson index	0.59 (0.05)	0.54 (0.05)	−0.05 (0.07)	0.43
Species richness	7.56 (0.73)	7.08 (0.69)	−0.48 (0.78)	0.55
Pielou’s evenness	0.54 (0.05)	0.55 (0.05)	0.01 (0.07)	0.87
% Lactobacillus	13.4 (6.3)	22.5 (5.5)	9.2 (8.3)	0.28

Bold: statistically significant, p<0.05