Table 3.
Correlation between CAST detection and past anti-CMV immunity in recipients before alloHCT and donors
| A. All recipients | |||
|---|---|---|---|
| Pre-alloHCT CASTs |
Anti-CMV IgG serology before alloHCT | p-value | |
| Negative (N=169) N (%) |
Positive (N=146) N (%) |
||
| < 1 cell / μL | 167 (99) | 66 (45) | <0.0001 |
| ≥ 1 cell / μL | 2 (1) | 80 (55) | |
| B. HLA matched sibling donors | |||
| Pre-alloHCT CASTs |
Anti-CMV IgG serology | p-value | |
| Negative (N=25) N (%) |
Positive (N=26) N (%) |
||
| < 1 cell / μL | 25 (100) | 6 (23) | <0.0001 |
| ≥ 1 cell / μL | 0 | 20 (77) | |
Abbreviations: alloHCT – allogeneic hematopoietic cell transplant, CAST – CMV antigen specific T cell, CMV – cytomegalovirus, HLA – human leukocyte antigen, IgG – immunoglobulin G, N – number