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Characterization of exosomes likely derived from CNS in human plasma. (A, B) Representative transmission electron microscopy (TEM) images of isolated exosomes. Scale bar: (A) 200 nm and (B) 100 nm. (C) Size distribution and concentration of isolated L1CAM exosomes evaluated by NanoSight. (D) The neuronal-derived exosomal markers L1CAM and other general exosomal markers (CD9, CD63 TSG101) expression in neuronal-derived blood exosomes as evaluated with Western blot
