Table 5.

Spearman’s rank correlation coefficient (rs) and P values between clinical variables and H&Y, MMSE, NMSS (total/domain) in PD patients

Variable	L1CAM exosomal Linc-POU3F3		L1CAM exosomal α-syn		Plasma α-syn		Exo/total α-syn		GCase activity
	r	P	r	P	r	P	r	P	r	P
Age	0.198	0.271	0.132	0.553	0.165	0.431	0.074	0.587	0.096	0.551
UPDRS	0.325	0.030	0.304	0.043	0.119	0.613	0.495	0.011	− 0.338	0.027
Up(I)	0.146	0.409	0.176	0.252	0.272	0.236	0.101	0.588	− 0.185	0.393
Up(II)	0.091	0.541	0.161	0.267	0.131	0.368	0.258	0.269	− 0.056	0.684
Up(III)	0.453	0.016	0.384	0.023	0.197	0.275	0.486	0.015	− 0.567	0.011
Up(IV)	0.134	0.395	0.040	0.715	0.035	0.746	0.206	0.266	−0.114	0.617
H&Y	0.412**	0.005	0.321*	0.033	0.144	0.413	0.351	0.028	− 0.369	0.028
MMSE	− 0.335*	0.027	− 0.064	0.639	− 0.050	0.661	− 0.110	0.573	0.551*	0.015
NMSS	0.155	0.398	0.093	0.578	0.065	0.681	0.086	0.614	0.044	0.709
Cardiovascular	0.075	0.618,	0.059	0.655	0.201	0.278	0.094	0.138	− 0.105	0.581
Sleep/fatigue	0.07,	0.713	0.417	0.064	0.048	0.705	0.026	0.831	− 0.078	0.702
Mood	0.430*	0.021	0.067	0.681	0.091	0.592	0.043	0.712	− 0.451**	0.004
Perceptual problem	0.126	0.432	0.080	0.653	0.185	0.105	0.076	0.606	− 0.153	0.464
Attention/memory	0.483*	0.018	0.109	0.576	0.241	0.376	0.143	0.420	− 0.418**	0.005
Gastrointestina	0.035	0.739	0.121	0.551	0.162	0.387	0.069	0.660	− 0.092	0.611
Urinar	0.122	0.443	0.090	0.581	0.028	0.186	0.123	0.548	− 0.025	0.833
Sexual function	0.095	0.607	0.033	0.806	0.197	0.454	0.083	0.651	− 0.117	0.615
Miscellaneous	0.012	0.895	− 0.107	0.579	− 0.101	0.485	− 0.411	0.029	− 0.144	0.420
Daily dose of L-Dopa (mg)	0.164	0.483	0.138	0.427	0.060	0.668	0.058	0.658	− 0.081	0.65

r_s, Spearman’s rank correlation coefficient; UPDRS, Unified Parkinson’s disease rating scale; H&Y, the modified Hoehn and Yahr staging scale; MMSE, mini-mental state examination; NMSS, non-motor symptoms scale for Parkinson’s disease; *P < 0.05, **P < 0.01