Table 1.
Participant characteristics in the GWAS of MTL substructures.
| Diagnosis | HC | EMCI | LMCI | AD | p-value |
|---|---|---|---|---|---|
| Number | 41 | 43 | 24 | 26 | - |
| Gender (M/F) | 20/21 | 24/19 | 13/11 | 16/10 | 0.64 |
| Age | 76.10±6.88 | 73.98±7.21 | 72.71±8.38 | 74.42±7.62 | 0.32 |
| Education | 17.00±2.30 | 17.14±2.70 | 16.50±3.13 | 16.35±2.50 | 0.57 |
| ICV (103 cm3) | 1.51±0. 15 | 1.54±0.12 | 1.47±0.13 | 1.52±0.18 | 0.27 |
| CA_L (103 mm3) | 1.37±0.18 | 1.34±0.19 | 1.22±0.28 | 1.10±0.28 | 1.44E-05 |
| CA_R (103 mm3) | 1.43±0.21 | 1.41±0.21 | 1.19±0.29 | 1.08±0.28 | 1.07E-08 |
| DG_L (103 mm3) | 0.77±0.11 | 0.76±0.12 | 0.70±0.19 | 0.65±0.14 | 1.08E-03 |
| DG_R (103 mm3) | 0.84±0.15 | 0.81±0.13 | 0.70±0.17 | 0.63±0.16 | 7.28E-08 |
| SUB_L (103 mm3) | 0.46±0.08 | 0.48±0.06 | 0.41±0.08 | 0.39±0.08 | 1.04E-05 |
| SUB_R (103 mm3) | 0.45±0.07 | 0.48±0.06 | 0.40±0.07 | 0.38±0.09 | 9.04E-08 |
| ERC_L (103 mm3) | 0.45±0.09 | 0.46±0.08 | 0.43±0.09 | 0.39±0.07 | 1.50E-02 |
| ERC_R (103 mm3) | 0.44±0.09 | 0.45±0.09 | 0.39±0.10 | 0.39±0.09 | 1.80E-02 |
| PHC_L (103 mm3) | 0.88±0.15 | 0.90±0.17 | 0.80±0.16 | 0.77±0.22 | 8.90E-03 |
| PHC_R (103 mm3) | 0.94±0.15 | 0.98±0.20 | 0.88±0.12 | 0.85±0.16 | 7.60E-03 |
| BA35_L (103 mm3) | 0.55±0.11 | 0.52±0.10 | 0.49±0.10 | 0.45±0.11 | 1.93E-03 |
| BA36_L (103 mm3) | 1.77±0.33 | 1.70±0.28 | 1.65±0.35 | 1.52±0.30 | 1.60E-02 |
| BA35_R (103 mm3) | 0.51±0.09 | 0.50±0.09 | 0.45±0.09 | 0.43±0.11 | 1.30E-03 |
| BA36_R (103 mm3) | 1.68±0.32 | 1.67±0.25 | 1.47±0.30 | 1.39±0.39 | 2.33E-04 |
Note: P-values were assessed for significant differences among diagnostic groups, and were computed using one-way ANOVA (except for gender using chi-square test). The p-values < 0.05 are shown in bold. HC = Healthy Control; EMCI = Early Mild Cognitive Complaint; LMCI = Late Mild Cognitive Complaint; AD = Alzheimer’s disease; ICV = Intracranial Volume.