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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Ophthalmol Retina. 2020 May 7;4(11):1069–1082. doi: 10.1016/j.oret.2020.04.029

Table 4.

Association of Averaged and Single Quantitative Metrics with DR Severity

Variable Association with DR Severity (Univariate Linear Regression) (Averaged Images) Association with DR Severity (Univariate Linear Regression) (Single Images)
Coefficient P Coefficient P
FAZ size 6.176 <0.001* 0.053 0.980
FAZ circularity −8.731 <0.001* −10.107 <0.001*
SRL superior VLD −0.776 <0.001* −0.769 <0.001*
SRL inferior VLD −0.550 0.001* −0.501 0.003*
SRL nasal VLD −0.888 <0.001* −0.711 <0.001*
SRL temporal VLD −0.759 <0.001* −0.679 <0.001*
SRL inner ring VLD −1.043 <0.001* −0.842 <0.001*
SRL total VLD −1.072 <0.001* −0.889 <0.001*
DRL superior VLD −0.692 <0.001* −0.809 <0.001*
DRL inferior VLD −0.746 <0.001* −0.767 <0.001*
DRL nasal VLD −0.687 <0.001* −0.692 <0.001*
DRL temporal VLD −0.631 <0.001* −0.580 <0.001*
DRL inner ring VLD −0.928 <0.001* −0.972 <0.001*
DRL total VLD −1.076 <0.001* −1.025 <0.001*
SRL superior PD −38.779 <0.001* −48.615 <0.001*
SRL inferior PD −8.409 0.471 −22.591 0.076
SRL nasal PD −27.511 0.012* −43.087 <0.001*
SRL temporal PD −26.017 0.016* −38.738 <0.001*
SRL inner ring PD −81.947 <0.001* −63.373 <0.001*
SRL total PD −89.717 <0.001* −63.405 <0.001*
DRL superior PD −32.065 <0.001* −43.458 <0.001*
DRL inferior PD −28.909 0.004* −40.900 <0.001*
DRL nasal PD −25.168 <0.001* −33.827 <0.001*
DRL temporal PD −31.889 <0.001* −31.376 <0.001*
DRL inner ring PD −66.395 <0.001* −61.989 <0.001*
DRL total PD −92.661 <0.001* −73.286 <0.001*

Results of univariate linear regressions for the ability of listed variables to predict worse DR severity. (+) coefficient = worse DR severity versus (−) coefficient = less DR severity.

DR severity was defined as a categorical variable with 0 = control, 1= diabetes without retinopathy, 2 = mild non-proliferative DR (NPDR), 3 = moderate NPDR, 4 = severe NPDR and 5 = proliferative DR. Bold (*) values denote significance set at P < 0.05. PD, perfusion density, is defined as the total area covered by perfused vasculature per unit area (%); VLD, vessel length density, is defined as the total length of perfused vasculature per unit area (mm/mm2). DR = diabetic retinopathy. DRL = deep retinal layer. FAZ = foveal avascular zone. SD = standard deviation. SRL = superficial retinal layer.