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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Infect Dis Clin North Am. 2020 Sep 30;34(4):773–819. doi: 10.1016/j.idc.2020.05.001

Table 6.

Mechanisms of resistance to meropenem-vaborbactam

Type Organism Mechanism(s) Minimum Inhibitory Concentraiton of Isolatea Reference
Survey K pneumoniae KPC, loss of ompK37 and up-regulation of AcrAB-TolC 16 177
Survey K pneumoniae KPC-2, TEM-181, SHV-11, loss of ompK35 and ompK36 16 173
Survey K pneumoniae KPC-2, TEM-1, SHV-11, SHV-12, loss of ompK35 and ompK36 32 173
Survey K pneumoniae KPC, loss of ompK35 and ompK36 32 174
Survey K pneumoniae KPC-2, SHV, TEM, OXA-10, loss of ompK35 and ompK36 64 178
Survey K pneumoniae KPC-3, SHV-11, SHV-12, loss of ompK35 and ompK36 16 178
Survey K pneumoniae KPC-3, SHV-11, loss of ompK35, ompK36, and ompK37 256 123
Survey K pneumoniae KPC-3, SHV-11, TEM1a, OXA-9, loss of ompK35, ompK36, and ompK37 256 123

Vaborbactam is maintained at 8 μg/mL when in combination with meropenem

E coli, K pneumoniae, and Enterobacter cloacae complex breakpoint: resistant ≥16 μg/mL.81

a

The MIC values for the isolate represent the MIC values obtained for either a clinical isolate obtained from a patient in a case study or part of a surveillance study or a laboratory-selected strain.

Data from Clinical and Laboratory Standards Institute (CLSI). M100: Performance Standards for Antimicrobial Susceptibility Testing. 30th ed.; 2020.