Fig. 7.
The effects of GW3965 on the expression changes of GABAAR and glutamate receptors in stressed amygdala. (a) Representative Western blot results showing the expression levels of GABAAR-α2 and GABAAR-γ2 subtypes under FS2 stress in the BLA of mice with or without GW3965 (GW, 10 mg/kg, i.p.) administration. The intensity of (b) GABAAR-α2 and (c) GABAAR-γ2 subtypes was normalized with endogenous β-actin and expressed as percent change compared with control. (d) Representative Western blot results showing the expression levels of NR2B, NR2A, phosphorylated GluR1 at S831/845 (p-GluR1–831/845), GluR1 and PSD95 in control, FS2, and FS2+GW groups. The intensity of (e) NR2B, (f) NR2A, (g) p-GluR1-831, (h) p-GluR1-845, and (i) PSD95 expression was normalized with endogenous β-actin and expressed as percent change compared with control. Error bars represented SEM. n = 4, *p < 0.05, **p < 0.01, versus control group; #p < 0.05, ##p < 0.01, versus FS2 group