Table 2.

Functional characterization of the lncRNAs in NP

LncRNA	Expression	Target genes	Related genes	Model	Region	Functions	Reference
XIST	Up	miR-150	ZEB1	CCI rat model	Spinal cord, microglial	Neuroinflammation	[102]
		miR-137	TNFAIP1	CCI rat model	Spinal cord, microglial	Neuroinflammation	[103]
		miR-154-5p	TLR5	CCI rat model	Spinal cord, microglial	Neuroinflammation	[104]
		miR-494	STAT3	SCI rat model	Spinal cord	Apoptosis	[105]
		miR-544	STAT3	CCI rat model	Spinal cord, microglial	Neuroinflammation	[18]
		miR-146a	Nav1.7	CFA rat model	DRG	Neuroinflammation	[106]
MALAT1	Up	miR-154-5p	AQP9	CCI rat model	Spinal cord, microglia	Neuroinflammation	[107]
		miR-129-5p	BDNF	PNI mice model	Schwann cell	Proliferation and migration	[108]
		miR-129-5p	HMGB1	CCI rat model	Spinal cord, microglia	Neuroinflammation	[109]
		miR-206	ZEB2	CCI rat model	Spinal cord, microglial	Neuroinflammation	[110]
uc.48+	Up	P2X7 receptor	p-ERK1/2	TN rat model	Trigeminal ganglia	Phosphorylation	[111]
			–	Diabetic rat model	DRG	Neuroinflammation	[112]
			p-ERK1/2	Diabetic rat model	Superior cervical ganglia	Autonomic neuropathy	[113]
BC168687	Up	P2X7 receptor	–	Diabetic rat model	DRG	Neuroinflammation	[114]
		TRPV1	TNF-α, IL-1β, ERK, MAPK	Diabetic rat model	DRG	Neuroinflammation	[115]
		P2X7, TRPV1 receptor	–	Diabetic rat model	DRG	Neuronal excitability	[116]
NONRATT021972	Up	P2X3 receptor	ERK1/2, p-ERK	Diabetic rat model	DRG	Neuroinflammation	[117]
		P2X7 receptor	–	Diabetic rat model	Superior cervical ganglion, PC12 cell	Neuroinflammation	[118]
		P2X7 receptor	–	Diabetic rat model	DRG	Neuroinflammation	[119]
BC088259	Up	Vimentin	–	SNI rat model	Schwann cell	Migration	[120]
Linc00657	Up	miR-136	ZEB1	CCI rat model	Spinal cord, microglial	Neuroinflammation	[121]
CRNDE	Up	miR-136	IL6R	CCI rat model	Spinal cord, microglial	Neuroinflammation	[122]
NEAT1	Up	miR-381	HMGB1	CCI rat model	Spinal cord, microglial	Neuroinflammation	[19]
uc.153	Up	miR-182-5p	EphB1-NMDA receptors	CCI mice model	Spinal cord	Neuronal excitability	[123]
Linc00052	Up	miR-448	JAK1	SNL rat model	Spinal cord, PC12 cell	Neuroinflammation	[124]
Linc00311, AK141205	Up	STAT3	CCL-2, COX-2, IL-1β, IL-6, and TNF-α	CCI rat model	Microglia	Neuroinflammation	[125]
SNHG5	Up	miR-154-5p	CXCL13	CCI rat model	DRG, microglia	Astrocyte inhibition, microglia activation	[126]
H19	Up	–	–	SNL rat model	DRG	Neuroinflammation	[127]
H19	Up	–	–	SNL mice model	DRG, DRG cell	Neuronal excitability	[128]
PKIA-AS1	Up	–	CDK6	SNL rat model	Spinal cord	Neuroinflammation	[129]
BC088327	Up	–	Heregulin-1β	PNI rat model	Sciatic nerve	Proliferation	[130]
MRAK009713	Up	P2X3 receptor	–	CCI rat model	DRG	Neuronal excitability	[131]
Kcna2 AS RNA	Up	Kcna2 mRNA	G9a	CCI/SNL mice model	DRG	Neuronal excitability	[132]
		Kcna2 mRNA	–	CCI/SNL rat model	DRG	Neuronal excitability	[133]
DGCR5	Down	miR-330-3p	PDCD4	CCI rat model	Spinal cord, microglial	Neuroinflammation	[134]
TNXA-PS1	Down	miR-24-3p/miR-152-3p	Dusp1	SNI rat model	DRG	Migration	[135]
CCAT1	Down	miR-155	SGK3	CCI rat model	DRG, spinal cord, hippocampus, anterior cingulate cortex, PC12 cell	Neuronal excitability	[136]
uc.217	Down	–	–	SNI rat model	DRG	Neurite outgrowth	[137]
BC089918	Down	–	–	SNI rat model	DRG	Nerve regeneration	[138]

CCI = sciatic nerve chronic constriction injury; SCI = spinal cord injury; CFA = complete Freund’s adjuvant; PNI = peripheral nerve injury; TN = trigeminal neuralgia; DRG = dorsal root ganglia; XIST = X-inactive specific transcript; ZEB1 = zinc finger E-box-binding homeobox 1; TNFAIP1 = tumor necrosis factor alpha-induced protein 1; TLR5 = toll-like receptor 5; STAT3 = signal transducer and activator of transcription 3; MALAT1 = metastasis-associated lung adenocarcinoma transcript 1; AQP9 = aquaporin 9; BDNF = brain-derived neurotrophic factor; HMGB1 = high mobility group protein B1; TRPV1 = transient receptor potential vanilloid type 1; IL = interleukin; TNF-α = tumor necrosis factor-α; ERK = extracellular regulated protein kinases; MAPK = mitogen-activated protein kinases; CRNDE = Colorectal Neoplasia Differentially Expressed; JAK1 = Janus kinase 1; CCL-2 = chemokine CC motif ligand 2; COX-2 = cyclooxygenase 2; SNHG5 = small nucleolar RNA host gene 5; CXCL13 = C-X-C motif chemokine 13; CDK6 = cyclin-dependent kinases 6; NF-κВ = nuclear factor-κВ; Dusp 1 = Dual-specificity phosphatase 1; CCAT1 = colon cancer–associated transcript-1; SGK3 = Serum and glucocorticoid–regulated protein kinase 3