Table 2.

Time to EDSS score ≥ 6.0 by initial treatment strategy (hazard ratios < 1.0 indicate more favorable outcome for induction)

	Hazard ratio	95% confidence intervals*		p value
		Lower bound	Upper bound
Case base scenario	0.48	0.18	0.97	0.024
Sensitivity analyses
(1) Model with time since first symptom as main time variable	0.54	0.15	0.96	0.037
(2) Model adjusted by all baseline variables	0.38	0.20	0.88	0.018
(3) Model adjusted by time on high-effective treatments	0.47	0.14	0.92	0.027
(4) Model built after matching in a 2:1 ratio	0.58	0.34	0.98	0.042

*Based on 1000 bootstrap samples (bias corrected and accelerated)