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. 2020 Nov 3;10:18879. doi: 10.1038/s41598-020-75306-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Microbiota of patients versus controls, the effect of EEN and differences between responders and non-responders. Panel (A) shows the difference in richness between controls and patients at T0. Panel (B) shows that EEN reduced diversity. Panel (C) and (D) show the effect of EEN on the proportional abundance of the Blautia and Subdoligranulum genera. Principal coordinate (PCoA) plots in panels (E) and (F) show separation of controls (red) and patients (blue), and responders (red) and non-responders (blue) at T0. In panels (G,H) and (I) some of the species that comprise the signature of responders versus non-responders at T0 are depicted. HC healthy controls, R responders, NR non-responders.