Figure 5.

A diet of amino acids worsens the murine DSS model of colitis. Mice received 1.5% DSS in their drinking water and were fed chow supplemented with milk protein (DSS milk protein) or an equivalent amount of amino acids (DSS Amino Acids). Control mice received milk protein (No DSS milk protein). Mice fed amino acids lost weight more rapidly (panel A), had increased stool, pathology and endoscopy scores, (panels B–D). Levels of TNFα, as measured by quantitative PCR, were elevated in both groups (panel E) whereas levels of IL-6, as measured by quantitative PCR, were only elevated in the group receiving amino acids (panels F).