Fig. 1.

Effect of different interventions on behavioral changes: (A) cold allodynia assessed by acetone drop test, (B) heat hyperalgesia assessed by hot plate test, (C) mechanical hyperalgesia assessed by pinprick test, and (D) mechanical dynamic allodynia assessed by paintbrush test before (day 1) and on the 7th and 14th days post-CCI. Data is expressed as mean ± SEM (n = 7-8) per group. ^*p < 0.05 versus sham group; ^#p < 0.05 versus CCI group; ^$p < 0.05 versus telmisartan group; ^@p < 0.05 versus losartan group, at the corresponding time points. CCI = chronic constriction injury