Fig. 6.

Upper panels: photomicrograph (H&E, × 400) of longitudinal sciatic nerve sections from normal (A), sham (B), CCI (C), pregabalin (D), losartan (E), enalapril (F), telmisartan (G), and ramipril (H). Rats received different treatments for 14 days, then they were sacrificed and tissues were collected. Arrows and arrowheads illustrate myelin sheaths’ degeneration and mononuclear infiltrating cells, respectively. S = Schwan cell nuclei; hg = hemorrhage. Scale bar, 50 μm. Lower panel: quantification of myelin damage of sciatic nerves of different groups represented in A–H using Nerve Injury Scoring System (NISS), and the scoring was 1 = normal, mild degeneration, or demyelination; 2 = moderate level of degeneration (< 50% damaged nerve tissue); and 3 = diffuse degeneration or demyelination (> 50% damaged nerve tissue). ^*p < 0.05 versus sham group; ^#p < 0.05 versus CCI group; ^@p < 0.05 versus losartan group; ^$p < 0.05 versus telmisartan group