Fig. 1.

The wake-promoting effect of modafinil in R6/2 and wild-type mice. The hourly amount of the time spent awake across 24 h after treatment with single doses of modafinil (25, 50, or 100 mg/kg; i.p., arrows) is shown compared to vehicle at the beginning of active (dark) phase in wild-type (a) and R6/2 mice aged 12 weeks (b) and 16 weeks (c). The black bar shows the dark period. $, #, and *p < 0.05, compared to the relevant vehicle in case of the 25, 50, and 100 mg/kg modafinil-treated groups, respectively. Data are presented as mean ± standard error of mean (SEM)