Table 1.

In vivo brain uptake and in vitro autoradiography of [¹⁸F]GE180 in rats after lithium-pilocarpine-induced SE

		Hippocampus		Thalamus		Piriform cortex
		Mean ± SD	p value	Mean ± SD	p value	Mean ± SD	p value
Uptake 1 week post-SE [%ID/g]	Vehicle	0.60 ± 0.08		0.57 ± 0.11		0.60 ± 0.11
	Mino 25	0.53 ± 0.13	0.434	0.47 ± 0.11	0.252	0.56 ± 0.13	0.792
	Mino 50	0.52 ± 0.08	0.328	0.44 ± 0.10	0.132	0.57 ± 0.11	0.814
Uptake 2 weeks post-SE [%ID/g]	Vehicle	0.47 ± 0.05		0.46 ± 0.05		0.50 ± 0.03
	Mino 25	0.43 ± 0.08	0.398	0.40 ± 0.07	0.192	0.46 ± 0.05	0.328
	Mino 50	0.45 ± 0.04	0.681	0.37 ± 0.03	0.023	0.50 ± 0.08	0.999
In vitro autoradiography 2 weeks post-SE [Bq/mm2]	Vehicle	42.89 ± 3.26		39.06 ± 1.34		49.14 ± 4.86
	Mino 25	42.46 ± 1.66	0.955	36.80 ± 2.00	0.733	47.66 ± 3.71	0.079
	Mino 50	41.66 ± 1.57	0.701	33.94 ± 1.31	0.018	41.63 ± 3.00	0.001

SE, status epilepticus; Mino, minocycline