FIGURE 1.

Experimental design. Cigarette smoke exposure occurred twice daily (from 10:00 h to 10:50 h and 15:00 h to 15:50 h) on weekdays (black arrow) with room air over the weekend (white arrow) for up to 24 weeks (left). In a subsequent group of mice, they followed the same cigarette smoke exposure for up to 4 weeks followed by an additional 4 weeks of room air exposure (gray arrows; right). Baseline recordings were made 1 week before exposure; sham animals were exposed to room air in the smoking chamber and used only for comparison to acute telemetry recordings.